Advanaced video coding for reducing complexity in H.264

Ph.DDOCTOR OF PHILOSOPH

Contaminated Confessions Revisited

A second wave of false confessions is cresting. In the first twenty-one years of post-conviction DNA testing, 250 innocent people were exonerated, forty of which had falsely confessed. Those false confessions attracted sustained public attention from judges, law enforcement, policymakers, and the media. Those exonerations not only showed that false confessions can happen, but did more by shedding light on the problem of confession contamination, in which details of the crime are disclosed to suspects during the interrogation process. As a result, false confessions can appear deceptively rich, detailed, and accurate. In just the last five years, there has been a new surge in false confessions — a set of twenty-six more false confessions among DNA exonerations. All but two of these most recent confessions included crime scene details corroborated by crime scene information. Illustrating the power of contaminated false confessions, in nine of the cases, defendants were convicted despite DNA tests that excluded them at the time. As a result, this second wave of false confessions should cause even more alarm than the first. In the vast majority of cases there is no evidence to test using DNA. Unless a scientific framework is adopted to regulate interrogations, including by requiring recording of entire interrogations, overhauling interrogation methods, providing for judicial review of reliability at trial, and informing jurors with expert testimony, the insidious problems of confession contamination will persist

Self-assembly of Nanometer-scale Magnetic Dots with Narrow Size Distributions on an Insulating Substrate

The self-assembly of iron dots on the insulating surface of NaCl(001) is investigated experimentally and theoretically. Under proper growth conditions, nanometer-scale magnetic iron dots with remarkably narrow size distributions can be achieved in the absence of a wetting layer Furthermore, both the vertical and lateral sizes of the dots can be tuned with the iron dosage without introducing apparent size broadening, even though the clustering is clearly in the strong coarsening regime. These observations are interpreted using a phenomenological mean-field theory, in which a coverage-dependent optimal dot size is selected by strain-mediated dot-dot interactions.Comment: 5 pages, 4 figure

Clinical Analysis of stereotactic body radiation therapy using extracranial gamma knife for patients with mainly bulky inoperable early stage non-small cell lung carcinoma

<p>Abstract</p> <p>Purpose</p> <p>To evaluate the clinical efficacy and toxicity of stereotactic body radiation therapy (SBRT) using extracranial gamma knife in patients with mainly bulky inoperable early stage non-small cell lung carcinoma (NSCLC).</p> <p>Materials and methods</p> <p>A total of 43 medically inoperable patients with mainly bulky Stage I/II NSCLC received SBRT using gamma knife were reviewed. The fraction dose and the total dose were determined by the radiation oncologist according to patients' general status, tumor location, tumor size and the relationship between tumor and nearby organ at risk (OAR). The total dose of 34~47.5 Gy was prescribed in 4~12 fractions, 3.5~10 Gy per fraction, one fraction per day or every other day. The therapeutic efficacy and toxicity were evaluated.</p> <p>Results</p> <p>The median follow-up was 22 months (range, 3-102 months). The local tumor response rate was 95.35%, with CR 18.60% (8/43) and PR 76.74% (33/43), respectively. The local control rates at 1, 2, 3, 5 years were 77.54%, 53.02%, 39.77%, and 15.46%, respectively, while the 1- and 2-year local control rates were 75% and 60% for tumor ≤3 cm; 84% and 71% for tumor sized 3~5 cm; 55% and 14.6% for tumor sized 5~7 cm; and 45%, 21% in those with tumor size of >7 cm. The overall survival rate at 1, 2, 3, 5 years were 92.04%, 78.04%, 62.76%, 42.61%, respectively. The toxicity of stereotactic radiation therapy was grade 1-2. Clinical stages were significantly important factor in local control of lung tumors (P = 0.000). Both clinical stages (P = 0.015) and chemotherapy (P = 0.042) were significantly important factors in overall survival of lung tumors.</p> <p>Conclusion</p> <p>SBRT is an effective and safe therapy for medically inoperable patients with early stage NSCLC. Clinical stage was the significant prognostic factors for both local tumor control and overall survival. The toxicity is mild. The overall local control for bulky tumors is poor. Tumor size is a poor prognostic factor, and the patients for adjuvant chemotherapy need to be carefully selected.</p

Macroscopic observations of diel fish movements around a shallow water artificial reef using a mid-frequency horizontal-looking sonar

Author Posting. © Acoustical Society of America, 2018. This article is posted here by permission of Acoustical Society of America for personal use, not for redistribution. The definitive version was published in Journal of the Acoustical Society of America 144 (2018): 1424-1434. doi:10.1121/1.5054013.The twilight feeding migration of fish around a shallow water artificial reef (a shipwreck) was observed by a horizontal-looking, mid-frequency sonar. The sonar operated at frequencies between 1.8 and 3.6 kHz and consisted of a co-located source and horizontal line array deployed at 4 km from the reef. The experiment was conducted in a well-mixed shallow water waveguide which is conducive to characterizing fish aggregations at these distances. Large aggregations of fish were repeatedly seen to emerge rapidly from the shipwreck at dusk, disperse into the surrounding area during the night, and quickly converge back to the shipwreck at dawn. This is a rare, macroscopic observation of an ecologically-important reef fish behavior, delivered at the level of aggregations, instead of individual fish tracks that have been documented previously. The significance of this observation on sonar performance associated with target detection in the presence of fish clutter is discussed based on analyses of echo intensity and statistics. Building on previous studies of long-range fish echoes, this study further substantiates the unique utility of such sonar systems as an ecosystem monitoring tool, and illustrates the importance of considering the impact of the presence of fish on sonar applications.We thank Jay Grove from the NOAA Southeast Fisheries Science Center for help in identifying potential fish species near the shipwreck sites. We also thank Jie Yang, B. Todd Hefner, and Kevin Williams at the Applied Physics Laboratory, University of Washington (APL-UW) for discussion on data processing and results interpretation. The study is supported by the Office of Naval Research and the Science & Engineering Enrichment & Development (SEED) Postdoctoral Fellowship from APL-UW.2019-03-1

A MODEL OF FUZZY TOPOLOGICAL RELATIONS FOR SIMPLE SPATIAL OBJECTS IN GIS

The goal of this paper is to present a new model of fuzzy topological relations for simple spatial objects in Geographic Information Sciences (GIS). The concept of computational fuzzy topological space is applied to simple fuzzy objects to efficiently and more accurately solve fuzzy topological relations, extending and improving upon previous research in this area. Firstly, we propose a new definition for simple fuzzy line segments and simple fuzzy regions based on computational fuzzy topology. And then, we also propose a new model to compute fuzzy topological relations between simple spatial objects, an analysis of the new model exposes:(1) the topological relations of two simple crisp objects; (2) the topological relations between one simple crisp object and one simple fuzzy object; (3) the topological relations between two simple fuzzy objects. In the end, we have discussed some examples to demonstrate the validity of the new model, through an experiment and comparisons of existing models, we showed that the proposed method can make finer distinctions, as it is more expressive than the existing fuzzy models

Metal-organic framework-derived Ni 2 P/nitrogen-doped carbon porous spheres for enhanced lithium storage

Transition metal phosphides (TMPs)/carbonaceous matrices have gradually attracted attention in the field of energy storage. In this study, we presented nickel phosphide (Ni2P) nanoparticles anchored to nitrogen-doped carbon porous spheres (Ni2P/NC) by using metal-organic framework-Ni as the template. The comprehensive encapsulation architecture provides closer contact among the Ni2P nanoparticles and greatly improves the structural integrity as well as the electronic conductivity, resulting in excellent lithium storage performance. The reversible specific capacity of 286.4 mA h g−1 has been obtained even at a high current density of 3.0 A g−1 and 450.4 mA h g−1 is obtained after 800 cycles at 0.5 A g−1. Furthermore, full batteries based on LiNi1/3Co1/3Mn1/3O2||Ni2P/NC exhibit both good rate capability and cycling life. This study provides a powerful and in-depth insight on new advanced electrodes in high-performance energy storage devices

Non-sterile fermentation of food waste using thermophilic and alkaliphilic Bacillus licheniformis YNP5-TSU for 2,3-butanediol production

Conversion of food waste into 2,3-butanediol (2,3-BDO) via microbial fermentation provides a promising way to reduce waste disposal to landfills and produce sustainable chemicals. However, sterilization of food waste, an energy- and capital-costly process, is generally required before fermentation to avoid any contamination, which reduces the energy net output and economic feasibility of food waste fermentation. In this study, we investigated the non-sterile fermentation of food waste to produce 2,3-BDO using a newly isolated thermophilic and alkaliphilic B. licheniformis YNP5-TSU. Three unitary food waste samples (i.e., pepper, pineapple, cabbage wastes) and one miscellaneous food waste mixture were respectively inoculated with B. licheniformis YNP5-TSU under non-sterile conditions. At 50 °C and an initial pH of 9.0, B. licheniformis YNP5-TSU was able to consume all sugars in food waste and produce 5.2, 5.9, 5.9 and 4.3 g/L of 2,3-BDO within 24 h from pepper, pineapple, cabbage and miscellaneous wastes, respectively, corresponding to a yield of 0.40, 0.38, 0.41 and 0.41 g 2,3-BDO/g sugar. These 2,3-BDO concentrations and yields from the non-sterile fermentations were comparable to those from the traditional sterile fermentations, which produced 4.0–6.8 g/L of 2,3-BDO with yields of 0.31–0.48 g 2,3-BDO/g sugar. Moreover, B. licheniformis was able to ferment various food wastes (pepper, pineapple and miscellaneous wastes) without any external nutrient addition and produce similar 2,3-BDO quantities. The non-sterile fermentation of food waste using novel thermophilic and alkaliphilic B. licheniformis YNP5-TSU provides a robust and energy-efficient approach to convert food waste to high-value chemicals

An MDM2 antagonist (MI-319) restores p53 functions and increases the life span of orally treated follicular lymphoma bearing animals

<p>Abstract</p> <p>Background</p> <p>MI-319 is a synthetic small molecule designed to target the MDM2-P53 interaction. It is closely related to MDM2 antagonists MI-219 and Nutlin-3 in terms of the expected working mechanisms. The purpose of this study was to evaluate anti-lymphoma activity of MI-319 in WSU-FSCCL, a B-cell follicular lymphoma line. For comparison purpose, MI-319, MI-219 and Nutlin-3 were assessed side by side against FSCCL and three other B-cell hematological tumor cell lines in growth inhibition and gene expression profiling experiments.</p> <p>Results</p> <p>MI-319 was shown to bind to MDM2 protein with an affinity slightly higher than that of MI-219 and Nutlin-3. Nevertheless, cell growth inhibition and gene expression profiling experiments revealed that the three compounds have quite similar potency against the tumor cell lines tested in this study. <it>In vitro</it>, MI-319 exhibited the strongest anti-proliferation activity against FSCCL and four patient cells, which all have wild-type p53. Data obtained from Western blotting, cell cycle and apoptosis analysis experiments indicated that FSCCL exhibited strong cell cycle arrest and significant apoptotic cell death; cells with mutant p53 did not show significant apoptotic cell death with drug concentrations up to 10 μM, but displayed weaker and differential cell cycle responses. In our systemic mouse model for FSCCL, MI-319 was tolerated well by the animals, displayed effectiveness against FSCCL-lymphoma cells in blood, brain and bone marrow, and achieved significant therapeutic impact (p < 0.0001) by conferring the treatment group a > 28% (%ILS, 14.4 days) increase in median survival days.</p> <p>Conclusion</p> <p>Overall, MI-319 probably has an anti-lymphoma potency equal to that of MI-219 and Nutlin-3. It is a potent agent against FSCCL <it>in vitro </it>and <it>in vivo </it>and holds the promises to be developed further for the treatment of follicular lymphoma that retains wild-type p53.</p